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KMID : 0613820120220091224
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Journal of Life Science
2012 Volume.22 No. 9 p.1224 ~ p.1230
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Gomisin A Inhibits Tumor Growth and Metastasis through Suppression of Angiogenesis
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Kim Do-Yoon
Yu Ho-Jin
Yoon Mi-So
Park Joo-Hoon
Jang Sang-Hee
Lee Hwan-Myung
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Abstract
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Cancer chemotherapy drugs command a large share of the market, and the development of new therapeutics with high efficacy and specificity is an active area of study. Recently, the development of cancer therapeutics from natural products targeting angiogenesis has drawn attention due to conventional chemotherapeutics showing serious side effects and resistance in cancer cells. In this study, we investigated the pharmacological efficacy of Gomisin A, an active ingredient of Schizandra chinensis baillon, on tumor growth and metastasis. Administration of Gomisin A at 10 and 100 μg/ml reduced tumor growth in vivo by 80.5±8.1% and 96.2±2%, respectively, compared with positive tumor controls. Treatment of Gomisin A in normal and various tumor cell lines did not exert significant toxicity. Mice treated with Gomisin A at a concentration of 10 and 100 μg/head showed a significant reduction in tumor-induced angiogenesis of 151±16.9% and 98.5±29.5%, respectively. Furthermore, tumor metastasis analysis revealed that the administration of Gomisin A at a concentration of 10 and 100 μg/head inhibited tumor metastasis by 13.5±8.56% and 58.3±9.12%, respectively. In addition, Gomisin A significantly decreased cell adhesion of the B16BL6 cells to the extracellular matrix. These results demonstrate that Gomisin A inhibits tumor growth via suppression of angiogenesis and tumor metastasis inhibition, without cellular toxicity. The pharmacological efficacy of Gomisin A suggests that it may be a potential candidate for the development of cancer drugs.
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KEYWORD
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Gomisin A, tumor growth, angiogenesis, metastasis, Schizandra chinensis
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